I'll go with SF vs Green Bay with the game being played in the city by the Bay (SF).........
Niner homer of course, but not really a homer pick. They have the best D in the NFC and with all 11 starters returning, plus natural improvement by younger players such as Alden Smith, Bowman (montster again this year) and Culliver, I expect an even better D this year.
As much as I wish we had a different QB, I'll give Alex the benefit of the doubt with his second year in the system and much improved weapons in the passing game with the additions of Moss, Manningham and Jenkins, plus James as a threat out of the backfield. If he improves as much this year as he did last year, he will be good enough to get them to the super bowl.
Tough conference. Giants and Saints, plus Philly, Detroit, Chicago, Atlanta and even Dallas have a legit shot to make it.